Research

Much of our work focuses on uncovering the function of neural circuits. Our overarching goal is to discover how neural circuits in the neocortex, basal ganglia, and thalamus contribute to sensorimotor integration in health and disease. Our research spans a range of scales from single neurons and microcircuitry to cortex-wide physiology and whole animal behavior. Our studies are backed by cutting-edge analytics leading to the discovery of fundamental insights into the function of the central nervous system.

Physiology

• Two photon and widefield calcium imaging

• Ex vivo slice recordings

• Optogenetics

• Peripheral measurements including pupil imaging and analysis

Behavior

• Head-fixed and freely moving behavior

• Widefield or two photon calcium imaging in head-fixed preparations

• Optogenetic control of neural circuits

Anatomy

• Laser scanning confocal microscopy

• Virally-delivered, genetically encoded neural circuit tracing

• Immunohistochemistry

• 3D reconstruction and quantification

Data lab

• Algorithm development

• Machine learning

• Scientific cloud architecture

• Cloud bioinformatics workflows

• Scientific app development